Non-clinical PhD students

 

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Alexia Martin 


Project title - Spatiotemporal 4D live imaging to characterise chromosomal instability and drug resistance in breast cancer organoids.

 

What were you doing before you joined the CSC Programme?

I studied BSc Medical Biosciences at Imperial College London 2018-2021. My bachelor’s project (Bernardino lab, NHLI) found that flavouring chemicals in vaping liquids can disrupt lung surfactant function. I also had a Summer Studentship and a Scientific Officer position at the Institute of Cancer Research validating triple-negative breast cancer treatment biomarkers (Tutt lab, BCN) prior to starting my PhD.

 

What inspired you to choose this project?

My interest is in translational research closely related to patient benefit. I also enjoy learning new imaging techniques and image analysis. My group at the ICR has strong links to the clinic, and in combination with the imaging expertise in my Imperial group, the collaborative project was perfect for me.

 

Interesting fact about yourself

I’m the “President” of my lab’s “Cake Club”. 

 

 

 

 

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Bastien Lecoeur 


Project title - Accelerating volumetric MR Imaging for Real-Time Adaptive Radiotherapy

 

What were you doing before you joined the CSC Programme?

Diplôme d’ingénieur généraliste (MSc in General Engineering), Telecom Paris - France (2018-2021)

MSc in Advanced Computing, Imperial College London (2020-2021)

 

What inspired you to choose this project?

I selected this project to be able to apply my computing skills to a real-life working scenario. I wanted to work towards helping patients with hard to treat cancers. 

 

Interesting fact about yourself

I have a white and ginger cat called Biscuit

 

 

 

 

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Pooja Kaur


Project title - Engineering next generation laminin targeted cancer immunotherapy 

 

 

 

 

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Elizabeth Flittner 

Project title - 'Molecular barcodes for high-dimensional functionalization of cancer heterogeneity

 

What were you doing before you joined the CSC Programme?

I completed my MSci Biochemistry at King’s College London 2017-2021. I undertook several placements throughout the degree which sparked my love for wet lab research.

 

What inspired you to choose this project?

I chose this project as it’s biotechnology heavy. I think creating novel bio-tools to help us better understand cancer is very important. 

 

Interesting fact about yourself

When I was a younger, I wanted to be a firefighter or a cancer researcher.

 

 

 

 

 

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Qiquan Wang

Project title - A Multimodal Topological Approach to Brain Cancer: Unifying Molecular and Imaging Data

 

What were you doing before you joined the CSC Programme?

I studied an integrated Master's in Mathematics at Imperial, where my Master’s project was studying a Bayesian model for player ranking in Tennis.

 

Interesting fact about yourself

I enjoy watching anime and doing outreach in my spare time.

 

 

 

 

 

Intercalated PhD students

 

 

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Leena Khelifa  

Project title - A Point-of-Care Diagnostic Device for Early Oncogene Detection in Cancer

 

 

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Daanyaal Khan 

Project title - Improving endometrial cancer diagnosis via detection of microRNA biomarkers from liquid biopsies: From biomarker discovery to screening test engineering

 

What inspired you to choose this project?

Endometrial Cancer is the most common gynaecological cancer in developed nations. Survival rates are incredibly good in the early stages of the disease but rapidly decrease in patients with advanced tumours. Symptoms of Endometrial Cancer are non-specific leading to only 20% of patients undergoing investigation for Endometrial cancer having confirmed disease. There is a clinically unmet need for a test that can reduce the number of patients undergoing painful and resource intensive investigations thereby reducing healthcare costs and improving peace of mind for patients. 

I am currently developing a Lateral flow test device using novel chemistry developed in the Ladame lab. To detect Endometrial cancer, I am utilising a new class of biomarkers: circulating miRNA. These biomarkers display tissue and disease specific profiles and can be quantified to determine not only disease presence. I have been interested in Cancer, detection and treatment since I was young.  Previously my focus was on monoclonal antibody treatments of non-small cell lung cancer. My interest on detection shifted after the passing of my grandmother from a rare form of endometrial cancer that went undetected due to its non-specific and atypical symptoms. With better detection and monitoring the hope is that more women will be able to access lifesaving treatments earlier. 

 

Interesting fact about yourself

I could recite the periodic table in order when I was 12.  

I spoke in the house of commons chamber when I was 16.  

Now I spend my free time trying to learn languages on Duolingo or getting crushed as white belt in bjj.  

 

 

 

 

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Edagul Ulucay 

Project title - Precise Photodynamic Therapy Of Oesophageal Cancer Using Bioharmonophores

 

What inspired you to choose this project?

Oesophageal cancer ranks as the sixth most common cause of cancer-related death worldwide. Survival rates have remained unsatisfactory, highlighting the need to improve existing therapeutic approaches. In response, my PhD focuses on pioneering a new approach to treat oesophageal cancer using bioharmonophores (biodegradable Second Harmonic Generating nanoprobes). These peptide-based nanoprobes hold great potential to radically improve photodynamic therapy in terms of depth of treatment field, precision targeting and efficacy. Motivated by my aspiration to become a proficient general surgeon, I chose this project with the aim of advancing patient care in the realm of cancer treatment. I hope this novel approach will improve the quality of life of cancer patients suffering with debilitating symptoms such as difficulty swallowing.

 

Interesting fact about yourself

I enjoy playing the piano as well as boxing and doing karate in my spare time. I’m also currently training for a half-marathon. 

 

 

 

 

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Melanie Herpels

Project title - Bioengineering tumor-targeted cytokines or chemotherapy for effective, specific and personalised immunotherapy combinations in pancreatic cancer

 

What inspired you to choose this project?

This project involves challenging cancer types that are currently treated with toxic chemotherapy, yet the success rates are low. I was determined to generate a form of immunotherapy that was more tolerable and effective. If successful, these sorts of agents could improve patient quality of life considerably. 

 

Interesting fact about yourself

I ran a half marathon at 17 years old and a full marathon at 19 years old.

 

 

 

 

Clinical research fellows

 

 

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Astrid Leusink 

Project title - MIBREAST Study: The IMpact of 3D Surface Imaging and Simulation on Shared Decision Making in Immediate Breast REconstruction And the Measurement of the EffectS of RadioTherapy

 

What inspired you to choose this project?

I chose this project because I believe it is a meaningful study that has the potential to greatly improve the quality of life of women undergoing breast reconstruction following mastectomy for breast cancer. 3D surface imaging and simulation has the potential to not only help prepare patients for their breast reconstruction surgery but also measure the effects of radiotherapy, improve surgical planning and reduce the need for future revisional surgery, which has a significant impact on the patient.  

 

Interesting fact about yourself

I am originally from Cape Town, South Africa and speak 5 languages  

 

 

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Daniel Westaby

Brian Hanley