Publications
Publications
Circulating tumor cells shed large extracellular vesicles in capillary-sized bifurcations - BioRxiv. April 20, 2024.
Angelos Vrynas, Sara Arfan, Karishma Satia, Salime Bazban-Shotorbani, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au
A first-in-human phase I study of the PD-1 inhibitor, retifanlimab (INCMGA00012), in patients with advanced solid tumors (POD1UM-101) - ESMO Open. 2024 Feb 21;9(4):102254.
Lakhani N, Cosman R, Banerji U, Rasco D, Tomaszewska-Kiecana M, Garralda E, Kornacki D, Li J, Tian C, Bourayou N, Powderly J.
The Lancet Commission on prostate cancer: planning for the surge in cases - Lancet. 2024 Apr 4:S0140-6736(24)00651-2
James ND, Tannock I, N'Dow J, Feng F, Gillessen S, Ali SA, Trujillo B, Al-Lazikani B, Attard G, Bray F, Compérat E, Eeles R, Fatiregun O, Grist E, Halabi S, Haran Á, Herchenhorn D, Hofman M, Jalloh M, Loeb S, MacNair A, Mahal B, Mendes L, Moghul M, Moore C, Morgans A, Morris M, Murphy D, Murthy V, Nguyen PL, Padhani A, Parker C, Rush H, Sculpher M, Soule H, Sydes MR, Tilki D, Tunariu N, Villanti P, Xie LP.
CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors - Clin Cancer Res. 2024 Apr 9:OF1-OF12.
Archer S, Brailey PM, Song M, Bartlett PD, Figueiredo I, Gurel B, Guo C, Brucklacher-Waldert V, Thompson HL, Akinwale J, Boyle SE, Rossant C, Birkett NR, Pizzey J, Maginn M, Legg J, Williams R, Johnston CM, Bland-Ward P, de Bono JS, Pierce AJ.
Validated machine learning tools to distinguish immune checkpoint inhibitor, radiotherapy, COVID-19 and other infective pneumonitis - Radiother Oncol. 2024 Apr 4:195:110266.
Hindocha S, Hunter B, Linton-Reid K, George Charlton T, Chen M, Logan A, Ahmed M, Locke I, Sharma B, Doran S, Orton M, Bunce C, Power D, Ahmad S, Chan K, Ng P, Toshner R, Yasar B, Conibear J, Murphy R, Newsom-Davis T, Goodley P, Evison M, Yousaf N, Bitar G, McDonald F, Blackledge M, Aboagye E, Lee R.
Characterizing functional DNA damage and response caused by the combination of CHK1 and WEE1 inhibitors in ovarian and breast cancer models - BJC Rep 2, 27 (2024).
Adam Stewart, Jiin Song, Lisa Pickard, Giovanna Muggiolu, Sylvie Sauvaigo, Alexis De Haven Brandon, Florence Raynaud & Udai Banerji
Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells - Cancer Discov. 2024 Mar 21:OF1-OF24.
Dalia Rosano, Emre Sofyali, Heena Dhiman, Chiara Ghirardi, Diana Ivanoiu, Timon Heide, Andrea Vingiani, Alessia Bertolotti, Giancarlo Pruneri, Eleonora Canale, Hannah F Dewhurst, Debjani Saha, Neil Slaven, Iros Barozzi, Tong Li, Grigory Zemlyanskiy, Henry Phillips, Chela James, Balázs Győrffy, Claire Lynn, George D Cresswell, Farah Rehman, Roberta Noberini, Tiziana Bonaldi, Andrea Sottoriva, Luca Magnani
The genomic trajectory of ovarian high grade serous carcinoma is determined in STIC lesions - BioRxiv preprint.
Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30 - RSC Chem Biol, 2024, Advance Article.
Milon Mondal, Fangyuan Cao, Daniel Conole, Holger W. Auner and Edward W. Tate.
Genome-wide mapping of G-quadruplex DNA: a step-by-step guide to select the most effective method - RSC Chem Biol, 2024, Advance Article.
Silvia Galli, Gem Flint, Lucie Růžičková and Marco Di Antonio
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity - Nat Rev Cancer. 2024 Mar 7.
Pascal Meier, Arnaud J. Legrand, Dieter Adam & John Silke
Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets - Nat Rev Cancer. 2024 Feb 29.
Edward W. Tate, Lior Soday, Ana Losada de la Lastra, Mei Wang & Hening Lin
Thio-2 inhibits key signaling pathways required for the development and progression of castration resistant prostate cancer - Mol Cancer Ther. 2024 Feb 27.
Antje Neeb, Ines Figueiredo, Denisa Bogdan, Laura Cato, Jutta Stober, Juan M Jiménez-Vacas, Victor Gourain, Irene I Lee, Rebecca Seeger, Claudia Muhle-Goll, Bora Gurel, Jonathan Welti, Daniel Nava Rodrigues, Jan Rekowski, Xintao Qiu, Yija Jiang, Patrizio Di Micco, Borja Mateos, Stasė Bielskutė, Ruth Riisnaes, Ana Ferreira, Susana Miranda, Mateus Crespo, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Stefan Bräse, Nicole Jung, Simone Gräßle, Amanda Swain, Xavier Salvatella, Stephen R Plymate, Bissan Al-Lazikani, Henry W Long, Wei Yuan, Myles Brown, Andrew C B Cato, Johann S de Bono, Adam Sharp
Circulating microRNA analysis in a prospective co-clinical trial identifies MIR652-3p as a response biomarker and driver of regorafenib resistance mechanisms in colorectal cancer - Clin Cancer Res. 2024 Feb 20.
Fiberbots: Robotic fibers for high-precision minimally invasive surgery - Sci Adv. 2024 Jan 19;10(3):eadj1984.
Mohamed E.M.K. Abdelaziz, Jinshi Zhao, Bruno Gil Rosa, Hyun-Taek Lee, Daniel Simon, Khushi Vyas, Bing Li, Hanifa Koguna, Yue Li, Ali Anil Demircali, Huseyin Uvet, Gulsum Gencoglan, Arzu Akcay, Mohamed Elriedy, James Kinross, Ranan Dasgupta, Zoltan Takats, Eric Yeatman, Guang-Zhong Yang, Burak Temelkuran
Deep Learning for Delineation of the Spinal Canal in Whole-Body Diffusion-Weighted Imaging: Normalising Inter- and Intra-Patient Intensity Signal in Multi-Centre Datasets - Bioengineering (Basel). 2024 Jan 29;11(2):130.
Antonio Candito, Richard Holbrey, Ana Ribeiro, Christina Messiou, Nina Tunariu, Dow-Mu Koh, Matthew D Blackledge
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase - J Med Chem. 2024 Jan 25;67(2):1061-1078.
Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A. Andrei, Olivia Boyd, Naoko Masumoto, Ursula R. Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I. Raynaud, Rosemary Burke, Julian Blagg, Henry S. Rzepa, Christian Siebold, Anthony I. Magee, Thomas Lanyon-Hogg, and Edward W. Tate
Real-time classification of tumour and non-tumour tissue in colorectal cancer using diffuse reflectance spectroscopy and neural networks to aid margin assessment - Int J Surg. 2024 Jan 22.
Scarlet Nazarian, Ioannis Gkouzionis, Jamie Murphy, Ara Darzi, Nisha Patel, Christopher J Peters, Daniel S Elson
A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation - Nat Biotechnol. 2024 Jan 8.
Cory A. Ocasio, Marc P. Baggelaar, James Sipthorp, Ana Losada de la Lastra, Manuel Tavares, Jana Volarić, Christelle Soudy, Elisabeth M. Storck, Jack W. Houghton, Susana A. Palma-Duran, James I. MacRae, Goran Tomić, Lotte Carr, Julian Downward, Ulrike S. Eggert & Edward W. Tate
Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation - J Clin Invest. 2024 Jan 16;134(2):e175369.
Magnus T Dillon, Jeane Guevara, Kabir Mohammed, Emmanuel C Patin, Simon A Smith, Emma Dean, Gemma N Jones, Sophie E Willis, Marcella Petrone, Carlos Silva, Khin Thway, Catey Bunce, Ioannis Roxanis, Pablo Nenclares, Anna Wilkins, Martin McLaughlin, Adoracion Jayme-Laiche, Sarah Benafif, Georgios Nintos, Vineet Kwatra, Lorna Grove, David Mansfield, Paula Proszek, Philip Martin, Luiza Moore, Karen E Swales, Udai Banerji, Mark P Saunders, James Spicer, Martin D Forster, Kevin J Harrington
Exposure to Aldehyde Cherry e-Liquid Flavoring and Its Vaping Byproduct Disrupt Pulmonary Surfactant Biophysical Function - Environ Sci Technol. 2024 Jan 8.
Alexia Martin, Carmelo Tempra, Yuefan Yu, Juho Liekkinen, Roma Thakker, Hayoung Lee, Berta de Santos Moreno, Ilpo Vattulainen, Christos Rossios, Matti Javanainen, Jorge Bernardino de la Serna
O-RADS MRI scoring system has the potential to reduce the frequency of avoidable adnexal surgery - Eur J Obstet Gynecol Reprod Biol. 2024 Jan 17:294:135-142.
Yohann Dabi, Andrea Rockall, Léo Razakamanantsoa, Adalgisa Guerra, Laure S Fournier, Christina Fotopoulou, Cyril Touboul, Isabelle Thomassin-Naggara; Eurad Study Group
2023
Optimizing the FDA's Project Optimus: opportunities and challenges - Nat Rev Clin Oncol. 2023 Dec 21.
Simon Rodney & Udai Banerji
Development and Evaluation of Machine Learning in Whole-Body Magnetic Resonance Imaging for Detecting Metastases in Patients With Lung or Colon Cancer: A Diagnostic Test Accuracy Study - Invest Radiol. 2023 Dec 1;58(12):823-831.
Rockall AG, Li X, Johnson N, Lavdas I, Santhakumaran S, Prevost AT, Punwani S, Goh V, Barwick TD, Bharwani N, Sandhu A, Sidhu H, Plumb A, Burn J, Fagan A, Wengert GJ, Koh DM, Reczko K, Dou Q, Warwick J, Liu X, Messiou C, Tunariu N, Boavida P, Soneji N, Johnston EW, Kelly-Morland C, De Paepe KN, Sokhi H, Wallitt K, Lakhani A, Russell J, Salib M, Vinnicombe S, Haq A, Aboagye EO, Taylor S, Glocker B.
Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation - J Clin Invest. 2023 Nov 7:e175369.
Dillon MT, Guevara J, Mohammed K, Patin EC, Smith SA, Dean E, Jones GN, Willis SE, Petrone M, Silva C, Thway K, Bunce C, Roxanis I, Nenclares P, Wilkins A, McLaughlin M, Jayme-Laiche A, Benafif S, Nintos G, Kwatra V, Grove L, Mansfield DC, Proszek P, Martin P, Moore L, Swales KE, Banerji U, Saunders MP, Spicer J, Forster MD, Harrington KJ.
The effect of nodal connectivity and strut density within stochastic titanium scaffolds on osteogenesis - Front Bioeng Biotechnol. 2023 Nov 29:11:1305936.
Stylianos Kechagias, Konstantinos Theodoridis, Joseph Broomfield, Kenny Malpartida-Cardenas, Ruth Reid, Pantelis Georgiou, Richard J van Arkel, Jonathan R T Jeffers
Repeatability of quantitative individual lesion and total disease multiparametric whole-body MRI measurements in prostate cancer bone metastases - Br J Radiol. 2023 Nov;96(1151):20230378.
Donners R, Candito A, Blackledge M, Rata M, Messiou C, Koh DM, Tunariu N.
Biocompatibility characterisation of CMOS-based Lab-on-Chip electrochemical sensors for in vitro cancer cell culture applications - Biorxiv. November 23, 2023.
Melina Beykou, Vicky Bousgouni, Nicolas Moser, Pantelis Georgiou, Chris Bakal
Radiomics-based decision support tool assists radiologists in small lung nodule classification and improves lung cancer early diagnosis - Br J Cancer. 2023 Nov 6.
Benjamin Hunter, Christos Argyros, Marianna Inglese, Kristofer Linton-Reid, Ilaria Pulzato, Andrew G. Nicholson, Samuel V. Kemp, Pallav L. Shah, Philip L. Molyneaux, Cillian McNamara, Toby Burn, Emily Guilhem, Marcos Mestas Nuñez, Julia Hine, Anika Choraria, Prashanthi Ratnakumar, Susannah Bloch, Simon Jordan, Simon Padley, Carole A. Ridge, Graham Robinson, Hasti Robbie, Joseph Barnett, Mario Silva, Sujal Desai, Richard W. Lee, Eric O. Aboagye & Anand Devaraj
Radium-223 in metastatic castration-resistant prostate cancer: whole-body diffusion-weighted magnetic resonance imaging scanning to assess response - JNCI Cancer Spectr. 2023 Oct 31;7(6):pkad077.
Parker C, Tunariu N, Tovey H, Alonzi R, Blackledge MD, Cook GJR, Chua S, Du Y, Hafeez S, Murray I, Padhani AR, Staffurth J, Tree A, Stidwill H, Finch J, Curcean A, Chatfield P, Perry S, Koh DM, Hall E.
Relative fat fraction of malignant bone lesions from breast cancer, prostate cancer and myeloma are significantly lower than normal bone marrow and shows excellent interobserver agreement. - Br J Radiol. 2023 Oct 31:20230240.
Castagnoli F, Donners R, Tunariu N, Messiou C, Koh DM.
Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma - Cell Rep. 2023 Oct 31;42(10):113307.
Yuewei Xu, Sarah Spear, Yurui Ma, Marc P Lorentzen, Michael Gruet, Flora McKinney, Yitao Xu, Chiharu Wickremesinghe, Madelen R Shepherd, Iain McNeish, Hector C Keun, Anke Nijhuis
Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance - Nature. 2023 Oct 16.
Christina Guo, Adam Sharp, Bora Gurel, Mateus Crespo, Ines Figueiredo, Suneil Jain, Ursula Vogl, Jan Rekowski, Mahtab Rouhifard, Lewis Gallagher, Wei Yuan, Suzanne Carreira, Khobe Chandran, Alec Paschalis, Ilaria Colombo, Anastasios Stathis, Claudia Bertan, George Seed, Jane Goodall, Florence Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Denisa Bogdan, Crescens Tiu, Reece Caldwell, Caterina Aversa, Ana Ferreira, Antje Neeb, Nina Tunariu, Daniel Westaby, Juliet Carmichael, Maria de los Dolores Fenor de la Maza, Christina Yap, Ruth Matthews, Hannah Badham, Toby Prout, Alison Turner, Mona Parmar, Holly Tovey, Ruth Riisnaes, Penny Flohr, Jesus Gil, David Waugh, Shaun Decordova, Anna Schlag, Bianca Calì, Andrea Alimonti & Johann S. de Bono
Ravindhi Murphy, Gurvin Chander, Maria Martinez, Caroline Ward, Sairah R. Khan, Mitesh Naik, Tara Barwick, Eric Aboagye, Rohini Sharma
The Biomarker Toolkit — an evidence-based guideline to predict cancer biomarker success and guide development - BMC Med. 2023 Oct 4;21(1):383.
Katerina-Vanessa Savva, Michal Kawka, Bhamini Vadhwana, Rahul Penumaka, Imogen Patton, Komal Khan, Claire Perrott, Saranya Das, Maxime Giot, Stella Mavroveli, George B Hanna, Melody Zhifang Ni, Christopher J Peters
Olaparib and celarasertib (AZD6738) in patients with triple negative advanced breast cancer: results from Cohort E of the plasmaMATCH trial (CRUK/15/010) - Clin Cancer Res. 2023 Sep 29.
Ring A, Kilburn LS, Pearson A, Moretti L, Afshari-Mehr A, Wardley AM, Gurel B, Macpherson IR, Riisnaes R, Baird RD, Martin S, Roylance R, Johnson H, Ferreira A, Winter MC, Dunne K, Copson E, Hickish T, Burcombe R, Randle K, Serra V, Llop-Guevara A, Bliss JM, Turner NC.
The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer - J Clin Invest. 2023 Sep 26:e169200.
Adamson B, Brittain N, Walker L, Duncan R, Luzzi S, Rescigno P, Smith GR, McGill S, Burchmore RJ, Willmore E, Hickson I, Robson CN, Bogdan D, Jimenez-Vacas JM, Paschalis A, Welti J, Yuan W, McCracken SR, Heer R, Sharp A, de Bono J, Gaughan L.
Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma - Br J Cancer. 2023 Sep;129(5):811-818.
Lopez J, Lai-Kwon J, Molife R, Welsh L, Tunariu N, Roda D, Fernández-García P, Lladó V, McNicholl AG, Rosselló CA, Taylor RJ, Azaro A, Rodón J, Sludden J, Veal GJ, Plummer R, Urruticoechea A, Lahuerta A, Mujika K, Escribá PV. A.
SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response - Nat Genet. 2023 Aug;55(8):1311-1323.
Philip Bland, Harry Saville, Patty T. Wai, Lucinda Curnow, Gareth Muirhead, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie Beatrix John, Somaieh Hedayat, Holly E. Barker, James Wright, Lu Yu, Ioanna Mavrommati, Abigail Read, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen N. Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Guy Pratt, …Rachael Natrajan
Development and Validation of a New BAG-1L-Specific Antibody to Quantify BAG-1L Protein Expression in Advanced Prostate Cancer - Lab Invest. 2023 Aug 29;103(11):100245.
Neeb A, Figueiredo I, Gurel B, Nava Rodrigues D, Rekowski J, Riisnaes R, Ferreira A, Miranda S, Crespo M, Westaby D, de Los Dolores Fenor de La Maza M, Guo C, Carmichael J, Grochot R, Tunariu N, Cato ACB, Plymate SR, de Bono JS, Sharp A.
The value of baseline 18F-sodium fluoride and 18F-choline PET activity for identifying responders to radium-223 treatment in castration-resistant prostate cancer bone metastases - Eur Radiol. 2023 Aug 24.
Donners R, Tunariu N, Tovey H, Hall E, Chua S, Cook G, Du Y, Blackledge MD, Parker CC, Koh DM.
The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells - Nat Cancer. 2023 Aug;4(8):1102-1121.
Brina D, Ponzoni A, Troiani M, Calì B, Pasquini E, Attanasio G, Mosole S, Mirenda M, D'Ambrosio M, Colucci M, Guccini I, Revandkar A, Alajati A, Tebaldi T, Donzel D, Lauria F, Parhizgari N, Valdata A, Maddalena M, Calcinotto A, Bolis M, Rinaldi A, Barry S, Rüschoff JH, Sabbadin M, Sumanasuriya S, Crespo M, Sharp A, Yuan W, Grinu M, Boyle A, Miller C, Trotman L, Delaleu N, Fassan M, Moch H, Viero G, de Bono J, Alimonti A.
openFrame: A modular, sustainable, open microscopy platform with single-shot, dual-axis optical autofocus module providing high precision and long range of operation - J Microsc. 2023 Aug 24.
Jonathan Lightley, Sunil Kumar, M Q Lim, E Garcia, F Görlitz, Y Alexandrov, T Parrado, C Hollick, E Steele, K Roßmann, J Graham, J Broichhagen, I A McNeish, C A Roufosse, M A A Neil, Chris Dunsby, P M W French
Accelerating 4D image reconstruction magnetic resonance-guided radiotherapy - Phys Imaging Radiat Oncol. 2023 Aug 23.
Participatory evaluation of the process of co-producing resources for the public on data science and artificial intelligence - Res Involv Engagem. 2023 Aug 14;9(1):67.
Piotr Teodorowski, Kelly Gleason, Jonathan J. Gregory, Martha Martin, Reshma Punjabi, Suzanne Steer, Serdar Savasir, Pournamy Vema, Kabelo Murray, Helen Ward & Dorota Chapko
The clinical terrain of immunotherapies in heterogeneous pancreatic cancer: unravelling challenges and opportunities - J Pathol. 2023 Aug 7.
Melanie Herpels, Jun Ishihara, Anguraj Sadanandam
Handheld ISFET Lab-on-Chip detection of TMPRSS2-ERG and AR mRNA for prostate cancer prognostics - IEEE Sens Lett. 2023 Aug;7(8):1-4.
Joseph Broomfield, Melpomeni Kalofonou, Sylvia Franklin, Sue M Powell, Thomas Pataillot-Meakin, Nicolas Moser, Charlotte L Bevan, Pantelis Georgiou
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target - Nat Metab. 2023 Aug;5(8):1303-1318.
Johan Vande Voorde, Rory T. Steven, Arafath K. Najumudeen, Catriona A. Ford, Alex Dexter, Ariadna Gonzalez-Fernandez, Chelsea J. Nikula, Yuchen Xiang, Lauren Ford, Stefania Maneta Stavrakaki, Kathryn Gilroy, Lucas B. Zeiger, Kathryn Pennel, Phimmada Hatthakarnkul, Efstathios A. Elia, Ammar Nasif, Teresa Murta, Eftychios Manoli, Sam Mason, Michael Gillespie, Tamsin R. M. Lannagan, Nikola Vlahov, Rachel A. Ridgway, Colin Nixon, Alexander Raven, Megan Mills, Dimitris Athineos, Georgios Kanellos, Craig Nourse, David M. Gay, Mark Hughes, Amy Burton, Bin Yan, Katherine Sellers, Vincen Wu, Kobe De Ridder, Engy Shokry, Alejandro Huerta Uribe, William Clark, Graeme Clark, Kristina Kirschner, Bernard Thienpont, Vivian S. W. Li, Oliver D. K. Maddocks, Simon T. Barry, Richard J. A. Goodwin, James Kinross, Joanne Edwards, Mariia O. Yuneva, David Sumpton, Zoltan Takats, Andrew D. Campbell, Josephine Bunch & Owen J. Sansom
Role of procalcitonin in predicting complications of Kawasaki disease - Arch Dis Child. 2023 Jul 31;archdischild-2023-325787.
Kazuki Iio, Heather Hanna, Melina Beykou, Chris Gale, Jethro Adam Herberg
Classification of nucleic acid amplification on ISFET arrays using spectrogram-based neural networks - Comput Biol Med. 2023 Jul;161:107027.
Prateek Tripathi, Costanza Gulli, Joseph Broomfield, George Alexandrou, Melpomeni Kalofonou, Charlotte Bevan, Nicolas Moser, Pantelis Georgiou
Unbiased differential proteomic profiling between cancer-associated fibroblasts and cancer cell lines - J Proteomics. 2023 Jul 20;104973.
Rachel Lau, Lu Yu, Theodoros I Roumeliotis, Adam Stewart, Lisa Pickard, Ruth Riisanes, Bora Gurel, Johann S de Bono, Jyoti S Choudhary, Udai Banerji
Proteome-wide structural analysis identifies warhead- and coverage-specific biases in cysteine-focused chemoproteomics - Cell Chem Biol. 2023 Jul 20;30(7):828-838.e4.
Matthew E.H. White, Jesus Gil, Edward W. Tate
Clinical trial designs for evaluating and exploiting cancer evolution - Cancer Treat Rev. 2023 Jul;118:102583.
Alvaro H Ingles Garces, Nuria Porta, Trevor A Graham, Udai Banerji
The potential role of the microbiota in prostate cancer pathogenesis and treatment. - Nat Rev Urol. 2023 Jul 25.
Pernigoni N, Guo C, Gallagher L, Yuan W, Colucci M, Troiani M, Liu L, Maraccani L, Guccini I, Migliorini D, de Bono J, Alimonti A.
Critical role of antioxidant programs in enzalutamide-resistant prostate cancer - Oncogene. 2023 Jul;42(30):2347-2359.
Blatt EB, Parra K, Neeb A, Buroni L, Bogdan D, Yuan W, Gao Y, Gilbreath C, Paschalis A, Carreira S, DeBerardinis RJ, Mani RS, de Bono JS, Raj GV.
A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer - Br J Cancer. 2023 Jul;129(1):38-45.
Rebecca Kristeleit, Ruth Plummer, Robert Jones, Louise Carter, Sarah Blagden, Debashis Sarker, Tobias Arkenau, Thomas R Jeffry Evans, Sarah Danson, Stefan N Symeonides, Gareth J Veal, Barbara J Klencke, Mark M Kowalski, Udai Banerji
Circulating Tumor Cell Cluster Sorting by Size and Asymmetry - Methods Mol Biol. 2023;2679:15-23.
Sam H Au
Dynamics and Molecular Interactions of GPI-Anchored CD59 - Toxins 2023, 15(7), 430.
Tomas B. Voisin, Emma C. Couves, Edward W. Tate and Doryen Bubeck
Cancer Loyalty Card Study (CLOCS): feasibility outcomes for an observational case-control study focusing on the patient interval in ovarian cancer - BMJ Open. 2023 Jun 14;13(6):e066022.
Hannah R Brewer, Marc Chadeau-Hyam, Eric Johnson, Sudha Sundar, James Flanagan, Yasemin Hirst
Immuno-PET Imaging of Tumour PD-L1 Expression in Glioblastoma - Cancers (Basel). 2023 Jun 9;15(12):3131.
Gitanjali Sharma, Marta C Braga, Chiara Da Pieve, Wojciech Szopa, Tatjana Starzetz, Karl H Plate, Wojciech Kaspera, Gabriela Kramer-Marek
Non-contrast CT synthesis using patch-based cycle-consistent generative adversarial network (Cycle-GAN) for radiomics and deep learning in the era of COVID-19 - Sci Rep. 2023 Jun 29;13(1):10568.
Reza Kalantar, Sumeet Hindocha, Benjamin Hunter, Bhupinder Sharma, Nasir Khan, Dow-Mu Koh, Merina Ahmed, Eric O. Aboagye, Richard W. Lee & Matthew D. Blackledge
The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer - Br J Cancer. 2023 Jun;128(12):2326-2337.
Theodora A. Constantin, Anabel Varela-Carver, Kyle K. Greenland, Gilberto Serrano de Almeida, Ellen Olden, Lucy Penfold, Simon Ang, Alice Ormrod, Damien A. Leach, Chun-Fui Lai, Edward K. Ainscow, Ash K. Bahl, David Carling, Matthew J. Fuchter, Simak Ali & Charlotte L. Bevan
Is tumour volume an independent predictor of outcome after radical prostatectomy for high-risk prostate cancer? - Prostate Cancer Prostatic Dis. 2023 Jun;26(2):282-286.
Nicholas Raison, Pol Servian, Amit Patel, Ainkaran Santhirasekaram, Andrew Smith, Maidie Yeung, Josephine Lloyd, Ethna Mannion, Andrea Rockall, Hashim Ahmed & Mathias Winkler
Hannah R. Brewer, Qianhui Jiang, Sudha Sundar, Yasemin Hirst, James M. Flanagan
Distributed large-scale graph processing on FPGAs - J Big Data. 2023;10(1):95.
Amin Sahebi, Marco Barbone, Marco Procaccini, Wayne Luk, Georgi Gaydadjiev, Roberto Giorgi
Advanced MR Techniques for Preoperative Glioma Characterization: Part 1 & Part 2 - J Magn Reson Imaging. 2023 Jun;57(6):1676-1695
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Capillary-Scale Hydrogel Microchannel Networks by Wire Templating - Small 2023 Jun 2;e2301163.
Shusei Kawara, Brian Cunningham, James Bezer, Neelima Kc, Jingwen Zhu, Meng-Xing Tang, Jun Ishihara, James J Choi, Sam H Au
A YOLOv5-based network for the detection of a diffuse reflectance spectroscopy probe to aid surgical guidance in gastrointestinal cancer surgery - Int J Comput Assist Radiol Surg. 2023 Jun 8.
Ioannis Gkouzionis, Yican Zhong, Scarlet Nazarian, Ara Darzi, Nisha Patel, Christopher J Peters, Daniel S Elson
Triaxial accelerometer-measured physical activity and functional behaviours among people with High Grade Glioma: The BrainWear Study - PLoS One. 2023 May 24;18(5):e0285399.
Seema Dadhania, Lillie Pakzad-Shahabi, Sanjay Mistry, Matt Williams
Imaging in metastatic breast cancer, CT, PET/CT, MRI, WB-DWI, CCA: review and new perspectives - Cancer Imaging. 2023 May 31;23(1):53.
Lother D, Robert M, Elwood E, Smith S, Tunariu N, Johnston SRD, Parton M, Bhaludin B, Millard T, Downey K, Sharma B.
Active mesh and neural network pipeline for cell aggregate segmentation - Biophys J. 2023 May 2;122(9):1586-1599.
Matthew B Smith, Hugh Sparks, Jorge Almagro, Agathe Chaigne, Axel Behrens, Chris Dunsby, Guillaume Salbreux
Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer - Microbiome. 2023 May 8;11(1):100.
James L. Alexander, Joram M. Posma, Alasdair Scott, Liam Poynter, Sam E. Mason, M. Luisa Doria, Lili Herendi, Lauren Roberts, Julie A. K. McDonald, Simon Cameron, David J. Hughes, Vaclav Liska, Simona Susova, Pavel Soucek, Verena Horneffer-van der Sluis, Maria Gomez-Romero, Matthew R. Lewis, Lesley Hoyles, Andrew Woolston, David Cunningham, Ara Darzi, Marco Gerlinger, Robert Goldin, Zoltan Takats, Julian R. Marchesi, Julian Teare & James Kinross
Asymmetric Dimethylation of Ribosomal S6 Kinase 2 Regulates Its Cellular Localisation and Pro-Survival Function - Int J Mol Sci. 2023 May 15;24(10):8806.
Mahmoud I Khalil, Heba M Ismail, Ganna Panasyuk, Anna Bdzhola, Valeriy Filonenko, Ivan Gout, Olivier E Pardo
Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth - Cell Death Discov. 2023 May 19;9(1):172.
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Ylenia Perone, Aaron J. Farrugia, Alba Rodríguez-Meira, Balázs Győrffy, Charlotte Ion, Andrea Uggetti, Antonios Chronopoulos, Pasquale Marrazzo, Monica Faronato, Sami Shousha, Claire Davies, Jennifer H. Steel, Naina Patel, Armando del Rio Hernandez, Charles Coombes, Giancarlo Pruneri, Adrian Lim, Fernando Calvo & Luca Magnani
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Annelie Johansson, Domenico Palli, Giovanna Masala, Sara Grioni, Claudia Agnoli, Rosario Tumino, Maria Concetta Giurdanella, Francesca Fasanelli, Carlotta Sacerdote, Salvatore Panico, Amalia Mattiello, Silvia Polidoro, Michael E. Jones, Minouk J. Schoemaker, Nick Orr, Katarzyna Tomczyk, Nichola Johnson, Olivia Fletcher, Vittorio Perduca, Laura Baglietto, Pierre-Antoine Dugué, Melissa C. Southey, Graham G. Giles, Dallas R. English, Roger L. Milne, Gianluca Severi, Srikant Ambatipudi, Cyrille Cuenin, Veronique Chajès, Isabelle Romieu, Zdenko Herceg, Anthony J. Swerdlow, Paolo Vineis & James M. Flanagan
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David J. Pinato, Matthew W. Brown, Sebastian Trousil, Eric O. Aboagye, Jamie Beaumont, Hua Zhang, Helen M. Coley, Francesco A. Mauri & Rohini Sharma
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Andrea Goya Grocin, Remigiusz A Serwa, Julia Morales Sanfrutos, Markus Ritzefeld, Edward W Tate
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Virginia Murillo-Garzón, Irantzu Gorroño-Etxebarria, Malin Åkerfelt, Mikael Christer Puustinen, Lea Sistonen, Matthias Nees, James Carton, Jonathan Waxman & Robert M. Kypta
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IPET study: an FLT-PET window study to assess the activity of the steroid sulfatase inhibitor irosustat in early breast cancer - Breast Cancer Res Treat. 2017 Nov;166(2):527-539.
Carlo Palmieri, Richard Szydlo, Marie Miller, Laura Barker, Neva H. Patel, Hironobu Sasano, Tara Barwick, Henry Tam, Dimitri Hadjiminas, Jasmin Lee, Abeer Shaaban, Hanna Nicholas, R. Charles Coombes & Laura M. Kenny
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Lesley-Ann Martin, Ricardo Ribas, Nikiana Simigdala, Eugene Schuster, Sunil Pancholi, Tencho Tenev, Pascal Gellert, Laki Buluwela, Alison Harrod, Allan Thornhill, Joanna Nikitorowicz-Buniak, Amandeep Bhamra, Marc-Olivier Turgeon, George Poulogiannis, Qiong Gao, Vera Martins, Margaret Hills, Isaac Garcia-Murillas, Charlotte Fribbens, Neill Patani, Zheqi Li, Matthew J Sikora, Nicholas Turner, Wilbert Zwart, Steffi Oesterreich, Jason Carroll, Simak Ali, Mitch Dowsett
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IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients - Breast Cancer Res Treat. 2017 Sep;165(2):343-353.
Carlo Palmieri, Rob C. Stein, Xinxue Liu, Emma Hudson, Hanna Nicholas, Hironobu Sasano, Fouzia Guestini, Chris Holcombe, Sophie Barrett, Laura Kenny, Sadie Reed, Adrian Lim, Larry Hayward, Sacha Howell & R. Charles Coombes On behalf of the IRIS trial participants
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WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response - Cell Death Dis. 2017 Jul 27;8(7):e2955.
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Engineering innovative solutions to screen for prostate cancer - Converg Sci Phys Oncol.
Dana Al Sulaiman, Gavin A D Metcalf and Sylvain Ladame
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Paula Cunnea, Sally Gowers, James E Moore Jr, Emmanuel Drakakis, Martyn Boutelle and Christina Fotopoulou
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Gavin A D Metcalf, Akifumi Shibakawa, Hinesh Patel, Ailsa Sita-Lumsden, Andrea Zivi, Nona Rama, Charlotte L Bevan, Sylvain Ladame
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Manikandan Periyasamy, Hetal Patel, Chun-Fui Lai, Van T M Nguyen, Ekaterina Nevedomskaya, Alison Harrod, Roslin Russell, Judit Remenyi, Anna Maria Ochocka, Ross S Thomas, Frances Fuller-Pace, Balázs Győrffy, Carlos Caldas, Naveenan Navaratnam, Jason S Carroll, Wilbert Zwart, R Charles Coombes, Luca Magnani, Laki Buluwela, Simak Ali
